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what i normally do is go with grid in order to reduce a 2-dimension page to a bunch of contexts i can then easily handle and refine with flex
IMHO they come together, there's no "this XOR that"
i don't know much about blueprint, but if you take the grid road, don't forget a fallback css for IE and older versions of chrome/FF -
Css grid and flex are really nice and widely supported nowadays. Why use a framework for it?
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It's not only about IE, a lot of browsers added support gradually. For full support of grid we're about 85% worldwide now. A missing 15% is still worth the effort IMHO, and the good thing about frameworks is that they come with premade fillers
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